John Trojanowski
John Q. John Q. Trojanowski, M.D., Ph.D., a physician, neuropathologist and scientist at University of Pennsylvania, a guy who identified major toxic proteins that drive many neurodegenerative diseases and developed animal models to match the discoveries, died on February 8th. He was 75. His findings over the decades would change what the field knew about conditions like Alzheimer's, Parkinson's disease, frontotemporal dementia and amyotrophic lateral sclerosis, offering evidence that the different toxic proteins share a common biological mechanism: they spread toxic proteins from cell to cell corrupting their normal counterpart to become toxic along the way, and in the end the brain may have many different toxic proteins, and not just the ones associated with a particular disease. Dr. Trojanowski was passionate about science and driven, and this gentle giant of a scientist -- he was 6'4 -- shared his scientific and personal life with his wife, Penn biochemist Virginia Lee. Their findings opened up new avenues of research in neurodegenerative diseases. The duo trained so many scientists over their 45 years together, and many credit their success to what they learned in the Trojanowski/ Lee lab. Dr. Trojanowski received his medical and doctoral degrees at Tufts University. He did graduate training in Rotterdam and came back to the states for his residency in neuropathology at Massachusetts General and Harvard Medical School. He met his life-long collaborator, Dr. Lee, in Massachusetts and the two of them moved to University of Pennsylvania in the early 1980s, and have been there since then. Dr. Trojanowski created so many firsts at UPenn, including a brain bank, the Alzheimer's Disease Research Center, and a center to develop drugs to target these toxic proteins. He was founding director of the ADRC, director at the Institute on Aging at Penn; director of the Morris K. Udall Parkinson's Disease Research Center of Excellence. John Trojanowski was one of seven children raised on Army bases throughout the country and in Guam. Their father was a career Army officer, and then settled into a comfortable career in real estate in Connecticut. He was passionate about science and knew he wanted to go to medical school, and not into the family business. He never looked back. He is survived by his wife, Dr. Lee, and his brother David and four of his other siblings. Dr. Lee and his other colleagues are planning a memorial symposium on neurodegeneration in the Fall.
•
Remembering John Trojanowski
Use the form below to make your memorial contribution. PRO will send a handwritten card to the family with your tribute or message included. The information you provide enables us to apply your remembrance gift exactly as you wish.